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Home Archives for Toxic

Public Health Alert

Quinine & Quinidine: Toxic Adulterants Found in Illicit Street Drugs

June 24, 2022

Quinine and its naturally occurring stereoisomer quinidine are natural alkaloids found in the bark of the cinchona tree, originally from South America. Today, quinine and quinidine are individually synthesized for…
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Public Health Alert

Bromazolam Prevalence Surging Across the United States Driven In Part by Increasing Detections Alongside Fentanyl

June 15, 2022

Bromazolam first emerged in the recreational drug supply in 2016 (Europe) and 2019 (United States). Bromazolam was first synthesized during medicinal drug development in the 1970s but never approved for…
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Public Health Alert

Synthetic Stimulant Market Rapidly Changing as N,N-Dimethylpentylone Replaces Eutylone in Drug Supply Typically Sold as “Ecstasy” or “Molly”

April 20, 2022

In 2020 and 2021, the substituted cathinone eutylone was the most commonly encountered synthetic stimulant to appear in forensic casework, despite the drug being considered federally scheduled as an isomer…
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Clinical Reports

Opioid Overdoses from the Toxicology Investigators Consortium (ToxIC) Fentalog Study Group: Q4 2021

December 16, 2021

A partnership between the American College of Medical Toxicology (ACMT) and the Center for Forensic Science Research and Education (CFSRE) was established to comprehensively assess the role and prevalence of…
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Public Health Alert

Adverse Effects Linked to Next Generation Opioids Reported in Patients Presenting to Emergency Departments After Suspected Opioid Overdose

December 3, 2021

The objective of this announcement is to notify public health and safety, clinicians, law enforcement, first responders, medical examiners and coroners, forensic and clinical laboratory personnel, and all other related…
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Clinical Reports

Opioid Overdoses from the Toxicology Investigators Consortium (ToxIC) Fentalog Study Group: Q3 2021

September 2, 2021

A partnership between the American College of Medical Toxicology (ACMT) and the Center for Forensic Science Research and Education (CFSRE) was established to comprehensively assess the role and prevalence of…
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Public Health Alert

Tramadol: A Toxic Adulterant Found in Illicit Street Drugs

May 28, 2021

Tramadol is a synthetic opioid analgesic approved in 1995 by the United States Food and Drug Administration (FDA) for moderate to moderately severe pain. Its mechanism of action involves opioid…
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Public Health Alert

Dipyrone (Metamizole): A Toxic Adulterant Found in Illicit Street Drugs

May 25, 2021

Dipyrone is a non-opioid analgesic with antipyretic activity, which was developed by the German company Hoechst AG in 1920 with mass production starting in 1922. It is a pro-drug, which…
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Clinical Reports

Opioid Overdoses from the Toxicology Investigators Consortium (ToxIC) Fentalog Study Group: Q2 2021

May 21, 2021

A partnership between the American College of Medical Toxicology (ACMT) and the Center for Forensic Science Research and Education (CFSRE) was established to comprehensively assess the role and prevalence of…
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Public Health Alert

Phenacetin: A Toxic Adulterant Found in Illicit Street Drugs

April 20, 2021

Phenacetin, a pain-relieving and fever-reducing drug, was discovered as an analgesic in 1887. It was one of the first synthetic fever reducers on the market and one of the first…
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