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Home Archives for overdose

Public Health Alert

Quinine & Quinidine: Toxic Adulterants Found in Illicit Street Drugs

June 24, 2022

Quinine and its naturally occurring stereoisomer quinidine are natural alkaloids found in the bark of the cinchona tree, originally from South America. Today, quinine and quinidine are individually synthesized for…
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Public Health Alert

Synthetic Stimulant Market Rapidly Changing as N,N-Dimethylpentylone Replaces Eutylone in Drug Supply Typically Sold as “Ecstasy” or “Molly”

April 20, 2022

In 2020 and 2021, the substituted cathinone eutylone was the most commonly encountered synthetic stimulant to appear in forensic casework, despite the drug being considered federally scheduled as an isomer…
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Clinical Reports

Opioid Overdoses from the Toxicology Investigators Consortium (ToxIC) Fentalog Study Group: Q4 2021

December 16, 2021

A partnership between the American College of Medical Toxicology (ACMT) and the Center for Forensic Science Research and Education (CFSRE) was established to comprehensively assess the role and prevalence of…
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Public Health Alert

Etodesnitazene — New Synthetic Opioid Identified During Forensic Death Investigations in the United States and Canada

December 14, 2021

Etodesnitazene is a new synthetic opioid bearing structural resemblance to etonitazene, a synthetic opioid that is nationally and internationally controlled. Etodesnitazene is dissimilar in structure to synthetic opioids typically encountered…
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Public Health Alert

New Synthetic Opioid Protonitazene Increasing in Prevalence as “Nitazenes” Gain Traction Across the United States and Canada

December 10, 2021

Protonitazene is a new, potent synthetic opioid bearing structural resemblance to etonitazene, a synthetic opioid that is nationally and internationally controlled. Protonitazene is dissimilar in structure to synthetic opioids typically…
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Public Health Alert

Adverse Effects Linked to Next Generation Opioids Reported in Patients Presenting to Emergency Departments After Suspected Opioid Overdose

December 3, 2021

The objective of this announcement is to notify public health and safety, clinicians, law enforcement, first responders, medical examiners and coroners, forensic and clinical laboratory personnel, and all other related…
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Clinical Reports

Opioid Overdoses from the Toxicology Investigators Consortium (ToxIC) Fentalog Study Group: Q3 2021

September 2, 2021

A partnership between the American College of Medical Toxicology (ACMT) and the Center for Forensic Science Research and Education (CFSRE) was established to comprehensively assess the role and prevalence of…
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Public Health Alert

New High Potency Synthetic Opioid N-Pyrrolidino Etonitazene (Etonitazepyne) Linked to Overdoses Across United States

June 17, 2021

N-Pyrrolidino etonitazene (etonitazepyne) is a new high potency synthetic opioid bearing structural resemblance to etonitazene, a synthetic opioid that is nationally and internationally controlled. N-Pyrrolidino etonitazene is dissimilar in structure…
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Public Health Alert

Tramadol: A Toxic Adulterant Found in Illicit Street Drugs

May 28, 2021

Tramadol is a synthetic opioid analgesic approved in 1995 by the United States Food and Drug Administration (FDA) for moderate to moderately severe pain. Its mechanism of action involves opioid…
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Public Health Alert

Dipyrone (Metamizole): A Toxic Adulterant Found in Illicit Street Drugs

May 25, 2021

Dipyrone is a non-opioid analgesic with antipyretic activity, which was developed by the German company Hoechst AG in 1920 with mass production starting in 1922. It is a pro-drug, which…
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Alex J. Krotulski, PhD
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