Fluorofentanyl was identified as early as 2016 in the U.S. and Europe, but overall detections remained low until recent months. Positivity of para-fluorofentanyl began increasing in Q3 2020 and within a few months this fentanyl analogue has been identified in 16 forensic cases. para-Fluorofentanyl is commonly found in combination with fentanyl, but the concentration ratio between these two substances varies (0.003 to 26); para-fluorofentanyl is the primary synthetic opioid in multiple cases. para-Fluorofentanyl is a potent synthetic opioid with reported potency similar to fentanyl.
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